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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
How often do perinatal events at full term cause cerebral palsy?
1Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB, Canada.
Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|May 29, 2008
Summary
Perinatal events contribute to cerebral palsy in full-term infants, with an incidence of 0.55 per 1000 deliveries. However, only a small fraction of these cases may be preventable with improved obstetric care.
Area of Science:
- Neurology
- Obstetrics
- Neonatology
Background:
- Cerebral palsy (CP) is a significant neurodevelopmental disorder.
- Understanding the contribution of perinatal events to CP in term infants is crucial for prevention strategies.
Purpose of the Study:
- To ascertain the role of perinatal events in the development of cerebral palsy among full-term newborns.
- To quantify the incidence of CP linked to perinatal factors.
Main Methods:
- A retrospective review of delivery records for term infants over an 11-year period at a tertiary care hospital.
- Detailed examination of obstetric histories and neonatal intensive care unit (NICU) charts for infants with specific conditions (encephalopathy, brain injury, asphyxia, infection, respiratory support).
- Medical record review to identify subsequent cerebral palsy diagnoses.
Main Results:
- Out of 36,368 term births, 20 infants were diagnosed with cerebral palsy attributed to perinatal insults.
- The incidence of perinatal-event-related cerebral palsy was 0.55 per 1000 term deliveries.
- Only six cases (0.17 per 1000 deliveries) were potentially preventable through enhanced obstetric care.
Conclusions:
- Perinatal events are a notable cause of cerebral palsy in full-term infants within this hospital cohort.
- The majority of perinatal-related cerebral palsy cases in term infants are not readily preventable by current obstetric practices.
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