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Updated: Jul 4, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
[Prevalence of thyroid autoimmune disease in patients with systemic lupus erythematosus]
Daniela P P Oliveira Viggiano1, Nilzio Antônio da Silva, Ana C O E Silva Montandon
1Departamento de Clínica Médica, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, GO, Brasil. danippo@ig.com.br
Introduction:
Thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including systemic lupus erythematosus (SLE).
Objective:
To estimate the prevalence of thyroid autoimmune diseases in patients with SLE.
Methods:
Transversal study to compare the prevalence of thyroid disorders in 106 patients with SLE and a control group of 102 patients. The patients were submitted to a clinical and a laboratorial evaluation; the tests included antiperoxidase and antithyroglobulin antibodies, TSH, free T4 and T3.
Results:
We detected high prevalence of subclinical hypothyroidism (11%) and clinical hypothyroidism (13%) in the group of patients with SLE when they were compared to the control group, 7% and 1%, respectively (p < 0.001). The hyperthyroidism occurred in a same frequency in the two groups. The positivity of antithyroid antibodies was higher in the group with SLE (23% versus 19%, p = 0.025). The relative risk of the patients with SLE to develop thyroid dysfunctions was 1,6.
Conclusion:
The thyroid disorders were more prevalent in patients with LES than in general population.
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