Related Experiment Video

Updated: Jul 4, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Pathologic roles of prorenin and (pro)renin receptor in the eye

Shingo Satofuka1, Atsuhiro Ichihara, Norihiro Nagai

  • 1Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.

Frontiers in Bioscience : a Journal and Virtual Library
|May 30, 2008
PubMed

Insights

A novel peptide targeting the (pro)renin receptor (PRR) suppressed ocular inflammation and neovascularization by inhibiting nonproteolytic prorenin activation. This highlights PRR

Area of Science:

  • Ophthalmology
  • Renal Physiology
  • Molecular Biology

Background:

  • Tissue renin-angiotensin system (RAS) is implicated in ocular inflammation and neovascularization.
  • The precise mechanism for activating tissue RAS, particularly nonproteolytic activation of prorenin, remained undefined.
  • The (pro)renin receptor (PRR) is a newly identified molecule that activates tissue RAS.

Purpose of the Study:

  • To investigate the role of nonproteolytic prorenin activation via PRR in ocular inflammation and neovascularization.
  • To evaluate the therapeutic potential of targeting PRR using a handle region peptide (HRP).

Main Methods:

  • Systemic administration of HRP, a decoy peptide targeting PRR.
  • Assessment of retinal inflammation and neovascularization in rodent models.
  • Measurement of retinal expression of RAS-related inflammatory and angiogenic molecules.

Main Results:

  • HRP treatment suppressed retinal inflammation and neovascularization in rodent models.
  • HRP inhibited the nonproteolytic activation of prorenin by binding to PRR.
  • Retinal expression of intercellular adhesion molecule-1, monocyte chemotactic protein-1, and vascular endothelial growth factor was reduced by HRP.

Conclusions:

  • Nonproteolytically activated prorenin plays a significant role in ocular inflammation and neovascularization.
  • Targeting the (pro)renin receptor with HRP is a promising therapeutic strategy for ocular inflammatory and neovascular diseases.

More Related Videos

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors12:03

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
Introduction to Urinary System01:13

Introduction to Urinary System

The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of each...