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Updated: Jul 4, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
Evolutionary constraints imposed by gene dosage balance
1Department of Ecology and Evolution, University of Chicago, IL 60637, USA. hliang@uchicago.edu
Abstract:
The gene dosage balance hypothesis states that a concentration imbalance among components of macromolecules is often deleterious. Thus this notion potentially provides a mechanistic explanation for understanding genetic dominance and gene duplicability. Accumulating evidence emerged from recent genomic data has strongly supported this hypothesis. Further efforts are needed to understand dosage sensitivity in the context of organismal complexity and co-regulation of genes under dosage-balance constraints.
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