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Updated: Jul 4, 2026
09:04
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Antisense DNA and RNA agents against picornaviruses
Travis Lim1, Jane Yuan, Huifang Mary Zhang
1Providence Heart and Lung Institute, Department of Pathology and Laboratory Medicine, University of British Columbia-St. Paul's Hospital, Vancouver, Canada.
Summary
Antisense oligonucleotides (ASO) and small interfering RNA (siRNA) show promise for treating picornavirus infections by inhibiting viral gene expression. Further research is needed to overcome limitations for clinical application.
Area of Science:
- Molecular Biology
- Virology
- Drug Development
Background:
- Nucleic acid-based molecules offer sequence-specific gene silencing.
- Antisense agents target viral translation/transcription via nuclease activity or physical hindrance.
- Key types include antisense oligonucleotides (ASO) and small interfering RNA (siRNA).
Purpose of the Study:
- To review the drug development of ASO and siRNA strategies against picornavirus infections.
- To discuss the design, modifications, and delivery of these antisense agents.
- To compare antisense agents with other therapeutics for picornavirus.
Main Methods:
- Review of existing literature on ASO and siRNA for picornavirus.
- Analysis of picornavirus genome organization and life cycle.
- Evaluation of design considerations, chemical modifications, and delivery approaches.
Main Results:
- ASO and siRNA are effective in inhibiting picornavirus replication.
- Various chemical modifications enhance stability and efficacy.
- Delivery methods are crucial for successful therapeutic application.
Conclusions:
- ASO and siRNA represent a promising therapeutic strategy for picornavirus infections.
- Overcoming limitations in delivery and stability is key for clinical translation.
- Antisense agents offer a distinct mechanism compared to traditional antivirals.
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