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Published on: October 26, 2020
Effect of apelin on glomerular hemodynamic function in the rat kidney
Annette Hus-Citharel1, Nadine Bouby, Alain Frugière
1INSERM, U 691, Paris, France.
Kidney International
|May 30, 2008
Summary
Apelin, a peptide, influences kidney function by affecting blood vessels in the glomeruli. It causes vasodilation and has complex effects on renal hemodynamics.
Area of Science:
- Nephrology
- Cardiovascular Physiology
- Endocrinology
Background:
- Apelin is a vasoactive peptide and the endogenous ligand for the APJ receptor.
- Both apelin and its receptor are present in the brain and cardiovascular system.
- The expression patterns of apelin receptor in the kidney were previously unknown.
Purpose of the Study:
- To investigate the role of the apelin-APJ system in renal microcirculation and hemodynamics.
- To determine the localization and function of apelin receptors in the kidney.
Main Methods:
- Quantitative analysis of apelin receptor mRNA expression in rat kidney tissues.
- In vivo studies involving intravenous injection of apelin 17 in lactating rats.
- Ex vivo assessment of arteriolar responses to apelin administration using isolated rat glomeruli.
Main Results:
- Apelin receptor mRNA is highly expressed in glomeruli and vascular cells of glomerular arterioles.
- Apelin administration induced diuresis and vasorelaxation of afferent and efferent arterioles.
- Apelin activated nitric oxide release, inhibiting angiotensin II-induced calcium increase, but also exhibited a vasoconstrictive effect.
Conclusions:
- Apelin exerts complex, receptor-mediated effects on pre- and post-glomerular microvasculature, regulating renal hemodynamics.
- Apelin's precise role in tubular function requires further investigation.
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