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Related Experiment Videos

Herpes simplex lymphadenitis.

M J Gaffey1, J M Ben-Ezra, L M Weiss

  • 1Division of Pathology, City of Hope National Medical Center, Duarte, California 91010.

American Journal of Clinical Pathology
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Localized herpetic lymphadenitis, a rare herpes simplex virus (HSV) complication, presents with necrotic lymph nodes. Most cases occur in inguinal nodes, often in patients with hematopoietic malignancies.

Area of Science:

  • Virology
  • Pathology
  • Immunology

Background:

  • Herpes simplex virus (HSV) infection is common, but localized herpetic lymphadenitis is an extremely rare complication.
  • Understanding the pathogenesis and clinical presentation of HSV lymphadenitis is crucial for accurate diagnosis and patient management.

Observation:

  • Two new cases of localized herpetic lymphadenitis are presented, characterized by well-circumscribed necrotic areas with intranuclear inclusions.
  • Diagnostic confirmation included electron microscopy showing viral particles and in situ hybridization detecting HSV DNA.
  • Immunohistochemistry revealed inclusions within stromal cells, not lymphoid cells.

Findings:

  • HSV lymphadenitis predominantly affects inguinal lymph nodes (7 out of 8 reported cases).
  • A significant association exists between HSV lymphadenitis and hematopoietic malignancies (4 out of 8 cases).

Related Experiment Videos

  • Both presented cases involved patients with diagnosed hematopoietic malignancies.

    • Implications:

    • This study highlights the importance of considering HSV lymphadenitis in the differential diagnosis of lymphadenopathy, particularly in immunocompromised patients.
    • The findings underscore the link between HSV infection and hematologic disorders, suggesting potential implications for disease monitoring and treatment.
    • Further research into the mechanisms underlying HSV lymphadenitis in the context of malignancy is warranted.