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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

[Prostate carcinoma in the elderly].

Alain Ravaud1, Gilles Pasticier, Jean-Louis Davin

  • 1Service d'oncologie médicale et de radiothérapie, hôpital Saint-André, CHU, 1, rue Jean-Burguet, 33075 Bordeaux Cedex, France. alain.ravaud@chu-bordeaux.fr

Bulletin Du Cancer
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

This review examines prostate carcinoma in elderly men, highlighting age as a key factor influencing disease presentation and treatment decisions. It also assesses the inclusion of older patients in clinical trials and adaptive therapies.

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Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Area of Science:

  • Geriatric oncology
  • Urologic oncology
  • Cancer epidemiology

Context:

  • Prostate carcinoma is the most prevalent cancer among men in France.
  • The review focuses specifically on prostate carcinoma within the elderly population.
  • Aging significantly impacts cancer presentation and management.

Purpose:

  • To review the role of age as a primary factor in prostate carcinoma.
  • To analyze how age affects disease presentation and prostate-specific antigen (PSA) levels.
  • To discuss the challenges and considerations in therapeutic decision-making for elderly patients with prostate carcinoma.

Summary:

  • Age is identified as the principal determinant in prostate carcinoma.
  • Disease characteristics and PSA levels are shown to vary with age.
  • The review addresses the complexities of treatment choices for older individuals.

Impact:

  • Provides insights into age-related prostate carcinoma presentation and PSA dynamics.
  • Guides therapeutic decision-making for elderly prostate carcinoma patients.
  • Evaluates the representation of elderly individuals in clinical research and personalized treatment strategies.