[Cryptogenic organizing pneumonia: typical and atypical imaging features on computed tomography]

Area of Science:

• Pulmonology
• Radiology
• Pathology

Background:

• Organizing pneumonia (OP) is a clinicopathological pattern of lung disease.
• It can be idiopathic (cryptogenic organizing pneumonia) or secondary to infections, drugs, autoimmune diseases, and other conditions.
• Understanding OP's diverse etiologies and manifestations is crucial for diagnosis.

Purpose of the Study:

• To provide a comprehensive overview of organizing pneumonia (OP).
• To describe the histopathological, clinical, and computed tomography (CT) imaging features of OP.
• To highlight classic and atypical CT findings associated with OP.

Main Methods:

• Review of histopathological findings in organizing pneumonia.
• Analysis of clinical presentations associated with OP.
• Detailed examination of CT imaging characteristics of OP, including common and uncommon patterns.

Main Results:

• OP exhibits characteristic histopathological features.
• Clinical symptoms vary widely, often mimicking other lung diseases.
• CT imaging shows classic peripheral and peribronchovascular consolidations and ground glass opacities.
• Atypical CT findings include nodules, crazy paving, lines, bands, perilobular consolidations, and the reversed halo sign.

Conclusions:

• Organizing pneumonia is a distinct histopathological pattern with varied clinical and imaging presentations.
• CT imaging plays a vital role in diagnosing OP, demonstrating both typical and unusual features.
• Recognizing the spectrum of OP manifestations is essential for accurate diagnosis and management.