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Updated: Aug 13, 2026

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
Published on: October 2, 2018
[Features of adrenal cortex function in heterozygous carriers of 21-hydroxylase deficiency]
Abstract:
Adrenocortical function in carriers of 21-hydroxylase insufficiency and in persons without it was investigated by change in the levels of 17-hydroxyprogesterone and dehydroepiandrosterone before and against a background of prolonged ACTH stimulation. Differences in change of the basal concentrations of these hormones in both groups were absent. Change of adrenocortical function in the carriers was observed against a background of ACTH stimulation only by the blood level of 17-hydroxyprogesterone. Prolonged ACTH stimulation revealed not only quantitative but also qualitative traits of adrenocortical function in carriers of 21-hydroxylase insufficiency. An algorithm for diagnosing this insufficiency was worked out.
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