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Related Experiment Video

Updated: Jul 4, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

The canine model with chronic, complete atrio-ventricular block.

Avram Oros¹, Jet D M Beekman, Marc A Vos

¹Department of Medical Physiology, Division Heart and Lungs, UMC Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands.

Pharmacology & Therapeutics

|June 3, 2008

Summary

Drug-induced Torsades de Pointes risk is linked to reduced repolarization reserve. A chronic atrio-ventricular block (CAVB) dog model shows promise for screening drugs affecting repolarization and predicting arrhythmias using beat-to-beat variability.

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Area of Science:

Cardiology
Pharmacology
Electrophysiology

Background:

Drug-induced Torsades de Pointes (TdP) risk is associated with a reduced repolarization reserve.
Impaired repolarization, often due to blocking drugs, can lead to dangerous ventricular arrhythmias.
Ventricular remodeling after atrio-ventricular node ablation increases susceptibility to repolarization-dependent arrhythmias.

Purpose of the Study:

To describe the cellular and molecular basis of ventricular remodeling.
To validate the chronic, complete atrio-ventricular block (CAVB) dog model for proarrhythmic drug screening.
To introduce beat-to-beat variability of repolarization as a novel predictive parameter.

Main Methods:

Review of literature on cellular and molecular mechanisms of ventricular remodeling.
Validation of the CAVB dog model in proarrhythmic drug screening.
Introduction and discussion of beat-to-beat variability of repolarization as a predictive tool.

Main Results:

Ventricular remodeling contributes to increased susceptibility to arrhythmias.
The CAVB dog model effectively mimics conditions relevant for proarrhythmic drug screening.
Beat-to-beat variability of repolarization shows potential as a surrogate predictive parameter for arrhythmias.

Conclusions:

Understanding ventricular remodeling is crucial for assessing proarrhythmic risk.
The CAVB dog model is a valuable tool for evaluating drug-induced arrhythmias.
Beat-to-beat variability of repolarization offers a promising new method for predicting proarrhythmic events.