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Density Gradient Multilayered Polymerization (DGMP): A Novel Technique for Creating Multi-compartment, Customizable Scaffolds for Tissue Engineering

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Gastric floating matrix tablets: design and optimization using combination of polymers.

Shailesh T Prajapati¹, Laxmanbhai D Patel, Dasharath M Patel

¹Department of Pharmaceutics, Shri Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India. stprajapati@gmail.com

Acta Pharmaceutica (Zagreb, Croatia)

|June 3, 2008

Summary

This study optimized a domperidone-loaded gastric floating drug delivery system (GFDDS) using hydroxypropyl methylcellulose, Carbopol, and sodium alginate. The developed model accurately predicts GFDDS performance for enhanced drug delivery.

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Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Gastric floating drug delivery systems (GFDDS) offer prolonged drug release and improved bioavailability.
Domperidone is a widely used antiemetic and prokinetic agent with a short half-life, necessitating controlled release formulations.

Purpose of the Study:

To develop and optimize a domperidone-loaded GFDDS.
To investigate the impact of key polymers on the floating and release characteristics of the GFDDS.

Main Methods:

Box-Behnken design was utilized to formulate GFDDS with varying concentrations of hydroxypropyl methylcellulose K4M (HPMC K4M), Carbopol 934P, and sodium alginate.
Floating lag time (FLT), total floating time (TFT), drug release kinetics (t50, n), and gel formation were evaluated.
Dissolution data was analyzed using the power law model.

Main Results:

HPMC K4M significantly influenced floating properties.
Carbopol 934P negatively affected floating but controlled drug release.
Sodium alginate was crucial for gel formation without impacting floating.
A quadratic model was successfully developed to predict GFDDS performance.

Conclusions:

The optimized GFDDS formulation demonstrates potential for sustained domperidone release.
The developed mathematical model provides a valuable tool for predicting and designing GFDDS with desired characteristics.
This study highlights the synergistic role of polymers in achieving effective GFDDS performance.