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Reversal of myocardial dysfunction due to brain injury

Jens Wippermann1, Gerardus Bennink, Thorsten Wittwer

  • 1Department of Cardiothoracic Surgery, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany. jens.wippermann@uk-koeln.de

Asian Cardiovascular & Thoracic Annals
|June 3, 2008
PubMed

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...