Related Experiment Video
Updated: Jul 4, 2026
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
[Bone disease with pain. Osteomyelitis in the long bone]
Masayuki Kawashima1, Mahito Kawashima
1Kawashima Orthopaedic Hospital.
Abstract:
In the present time various antibiotics have been developed. But suppurative osteomyelitis has been very difficult to cure still up to now. If it fails to treat at the initial treatment, it recurs often. Many patients are annoyed by the recurrence. Moreover, increase of multiple resistance bacteria, opportunistic infection and traumatic osteomyelitis make them complex to treat. We have treated 256 osteomyelitis patients by debriding the infected area with closed irrigation before 1981. Then we have been treated 553 patients with Hyperbaric Oxygen Therapy (HBOT) . Include closed irrigation therapy, 95% of cases a good result occurred. The case that has fistula, sequestrum, foreign material or vast range of osteonecrosis is difficult to calm completely by only HBOT. In such cases, they should be taken curettage and closed irrigation.
Insights
Suppurative osteomyelitis remains challenging despite antibiotics. Hyperbaric Oxygen Therapy (HBOT) combined with closed irrigation shows a 95% success rate for osteomyelitis treatment, especially for complex cases.
Area of Science:
- Orthopedics
- Infectious Diseases
- Hyperbaric Medicine
Context:
- Suppurative osteomyelitis presents persistent treatment challenges.
- Recurrence is common, exacerbated by antibiotic resistance and complex infections.
- Traditional debridement with closed irrigation was used prior to 1981.
Purpose:
- To evaluate the efficacy of Hyperbaric Oxygen Therapy (HBOT) in treating suppurative osteomyelitis.
- To compare outcomes of HBOT with previous debridement and irrigation methods.
Summary:
- A total of 809 osteomyelitis patients were treated; 256 with debridement and irrigation, and 553 with HBOT.
- The study reported a 95% success rate when HBOT was combined with closed irrigation therapy.
- Complex cases involving fistula, sequestrum, foreign material, or extensive osteonecrosis required adjunctive curettage and irrigation.
Impact:
- HBOT offers a highly effective treatment modality for suppurative osteomyelitis.
- Combined therapy improves outcomes in complicated osteomyelitis cases.
- This research highlights the importance of tailored treatment approaches for diverse osteomyelitis presentations.
Related Concept Videos
01:29Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:17Gross Anatomy of Bone
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
01:55Bone Structure
01:02What is the Skeletal System?
01:27Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...