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Updated: Jul 4, 2026

18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
[Bone disease with pain. Osteomyelitis in the long bone]
Masayuki Kawashima1, Mahito Kawashima
1Kawashima Orthopaedic Hospital.
Summary
Suppurative osteomyelitis remains challenging despite antibiotics. Hyperbaric Oxygen Therapy (HBOT) combined with closed irrigation shows a 95% success rate for osteomyelitis treatment, especially for complex cases.
Area of Science:
- Orthopedics
- Infectious Diseases
- Hyperbaric Medicine
Context:
- Suppurative osteomyelitis presents persistent treatment challenges.
- Recurrence is common, exacerbated by antibiotic resistance and complex infections.
- Traditional debridement with closed irrigation was used prior to 1981.
Purpose:
- To evaluate the efficacy of Hyperbaric Oxygen Therapy (HBOT) in treating suppurative osteomyelitis.
- To compare outcomes of HBOT with previous debridement and irrigation methods.
Summary:
- A total of 809 osteomyelitis patients were treated; 256 with debridement and irrigation, and 553 with HBOT.
- The study reported a 95% success rate when HBOT was combined with closed irrigation therapy.
- Complex cases involving fistula, sequestrum, foreign material, or extensive osteonecrosis required adjunctive curettage and irrigation.
Impact:
- HBOT offers a highly effective treatment modality for suppurative osteomyelitis.
- Combined therapy improves outcomes in complicated osteomyelitis cases.
- This research highlights the importance of tailored treatment approaches for diverse osteomyelitis presentations.
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