Related Experiment Video
Updated: Jul 4, 2026
04:01
Revealing the Ferroptotic Phenotype of Medulloblastoma
Published on: March 15, 2024
Caseinophosphopeptide-bound iron: protective effect against gut peroxidation
Ida Kibangou1, Saïd Bouhallab, François Bureau
1Laboratoire de Physiologie Digestive et Nutritionnelle, CHU de Caen, Caen, France.
Annals of Nutrition & Metabolism
|June 3, 2008
Summary
Cow
Area of Science:
- Nutritional Science
- Biochemistry
- Gastroenterology
Background:
- Cow's milk peptides show in vitro protection against iron-induced peroxidation.
- This protective effect may mitigate side effects of iron fortification.
Purpose of the Study:
- To validate the in vitro protective effects of cow's milk peptides against gut peroxidation in an in vivo model.
- To compare the efficacy of iron bound to beta-casein phosphopeptide [Fe-beta-CPP(1-25)] with encapsulated ferric pyrophosphate (Fe-P) and ferrous sulfate (FeSO(4)).
Main Methods:
- Utilized the Caco-2 cell model to simulate gut peroxidation.
- Measured malondialdehyde (MDA) levels as a marker of lipid peroxidation.
- Compared iron absorption, cellular uptake, and basolateral transfer of Fe-beta-CPP(1-25) and Fe-P.
Main Results:
- Fe-beta-CPP(1-25) demonstrated the lowest MDA levels, indicating reduced peroxidation.
- Iron absorption was highest with Fe-beta-CPP(1-25) due to superior cellular uptake and basolateral transfer.
- Fe-P showed high uptake but significant cell retention, with higher MDA levels.
Conclusions:
- Beta-casein phosphopeptide (beta-CPP(1-25)) enhances iron absorption while protecting enterocytes from peroxidation.
- This protective effect may be linked to lower enterocyte storage of Fe-beta-CPP(1-25).
- Specific milk components like beta-CPP(1-25) show promise for improving iron fortification strategies to combat iron deficiency.
Related Concept Videos
01:17Oxidation of Phenols to Quinones
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
01:20Radical Autoxidation
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining. Bicarbonate,...
01:24Peroxisomes
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
01:16Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
02:49Corrosion
The degradation of metals due to natural electrochemical processes is known as corrosion. Rust formation on iron, tarnishing of silver, and the blue-green patina that develops on copper are examples of corrosion. Corrosion involves the oxidation of metals. Sometimes it is protective, such as the oxidation of copper or aluminum, wherein a protective layer of metal oxide or its derivatives forms on the surface, protecting the underlying metal from further oxidation. In other cases, corrosion is...