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Updated: Jul 4, 2026

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

A practical approach to using mice in atherosclerosis research.

Stewart C Whitman¹

¹The University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada. swhitman@ottawaheart.ca

The Clinical Biochemist. Reviews

|June 3, 2008

Summary

This review guides researchers on using mouse models for atherosclerosis studies. It details lesion types, formation timing, and analysis methods for apolipoprotein E deficient and LDL receptor deficient mice.

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Area of Science:

Cardiovascular Research
Animal Models
Atherosclerosis Research

Background:

Mice are widely used animal models for studying atherosclerosis.
Apolipoprotein E (apoE) deficient and low-density lipoprotein (LDL) receptor deficient mice are common models.
Researchers new to these models require guidance on experimental design and analysis.

Purpose of the Study:

To provide a practical guide for researchers using mouse models of atherosclerosis.
To detail the characteristics of lesions in apoE and LDL receptor deficient mice.
To outline methods for analyzing atherosclerotic lesions in these models.

Main Methods:

Review of current literature on mouse models of atherosclerosis.
Description of lesion types and their expected formation timelines.

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Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

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Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

Summary of biochemical and morphometric analysis techniques.

Main Results:

ApoE and LDL receptor deficient mice develop distinct atherosclerotic lesion profiles.
Specific age ranges are associated with the development of different lesion types.
Standardized methods exist for lesion quantification and characterization.

Conclusions:

Effective use of mouse models requires understanding lesion progression and analysis techniques.
ApoE and LDL receptor deficient mice offer valuable insights into atherosclerosis.
This review serves as a foundational resource for planning atherosclerosis experiments in mice.