Stem cells: implications in experimental ischaemic stroke therapy

Ischaemic stroke is a syndrome characterized by rapid onset of neurological injury due to interruption of blood flow to the brain. Widespread neuronal damage throughout the CNS has been shown to cause marked and multifarious functional impairments in the ischaemic brain. Recent advances as enumerated above have propelled acute ischaemic stroke management into a therapeutic era. However, once the damage from a stroke event has maximized, little can be done to recover premorbid function. Experimental animal data suggests that stem cell therapy may be an effective alternate to the conventional disease management strategies of ischaemic stroke. Therefore, the present review focuses on detailing the scope of stem cell therapy in the treatment of ischaemic stroke.