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Law of Segregation

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Discerning the Mauve factor, Part 2.

Woody R McGinnis1, Tapan Audhya, William J Walsh

  • 1Oxidative Stress in Autism Study, Auckland, New Zealand.

Alternative Therapies in Health and Medicine
|June 4, 2008
PubMed
Summary
This summary is machine-generated.

Hydroxyhemopyrrolin-2-one (HPL) is linked to stress and oxidative stress. Nutrient treatment, especially vitamin B6 and zinc, reduces HPL levels and improves neurobehavioral symptoms.

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Area of Science:

  • Biochemistry
  • Neurobiology
  • Nutritional Science

Background:

  • Hydroxyhemopyrrolin-2-one (HPL), previously mistaken for kryptopyrrole, is the hydroxylactam of hemopyrrole.
  • Elevated HPL excretion is associated with emotional and oxidative stress.
  • Nutrient supplementation, particularly vitamin B6 and zinc, can reduce HPL levels and improve neurobehavioral symptoms.

Purpose of the Study:

  • To examine the relationship between urinary HPL, nutritional status markers, and oxidative stress markers.
  • To investigate HPL as a potential biomarker for oxidative stress and its connection to intestinal permeability.

Main Methods:

  • Correlated 24-hour urinary HPL with red cell vitamin B6 activity and zinc concentration.
  • Assessed HPL correlation with plasma glutathione (GSH), red cell catalase, and plasma nitric oxide.
  • Examined the relationship between urinary HPL and urinary indicans as a marker for intestinal permeability.

Main Results:

  • Urinary HPL correlated negatively with vitamin B6 and zinc levels (P < .0001).
  • Above-normal HPL correlated with subnormal vitamin B6 and zinc.
  • HPL inversely correlated with plasma GSH and red-cell catalase, and directly with plasma nitric oxide (P < .0001).
  • Urinary HPL associated with higher levels of urinary indicans (P < .0001).

Conclusions:

  • Urinary HPL is a promising biomarker for oxidative stress and indicates a need for vitamin B6 and zinc.
  • HPL may contribute to oxidative stress by affecting heme metabolism, lowering zinc, and increasing nitric oxide.
  • Stress-related changes in intestinal permeability may influence HPL concentrations, suggesting a potential enterobiotic role.