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Updated: Jul 4, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Transfusion associated graft versus host disease.

Hamid Nawaz Tipu¹, Tahir Aziz Ahmed, Khalilullah

¹Armed Forces Institute of Pathology, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association

|June 4, 2008

Summary

Transfusion-associated graft-versus-host disease (TA-GVHD) occurred in an immunocompetent patient after receiving blood from a relative. Diagnosis was confirmed using HLA typing and STR analysis.

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Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

Immunology
Hematology
Genetics

Background:

Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but serious complication of blood transfusions.
It typically affects immunocompromised individuals, making this case in an immunocompetent host noteworthy.

Observation:

An immunocompetent female patient developed symptoms consistent with TA-GVHD post-transfusion.
The transfusion was administered from a close relative, suggesting potential donor-recipient genetic disparity.

Findings:

Human Leukocyte Antigen (HLA) typing confirmed a significant mismatch between the patient and the relative donor.
Short Tandem Repeat (STR) analysis further corroborated the familial relationship and provided genetic linkage data.

Implications:

This case highlights the risk of TA-GVHD even in immunocompetent recipients, particularly with related donors.
Emphasizes the importance of HLA-compatible or irradiated blood products in specific transfusion scenarios.
Underscores the utility of HLA typing and STR analysis in diagnosing transfusion complications.