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Related Concept Videos

Transport Number01:31

Transport Number

The transport number is the fraction of the total current carried by an ion in an electrolyte solution. It is defined as the ratio of the current carried by a specific ion to the total current flowing through the solution. The transport number, t, is central to understanding ionic mobility, which describes how fast an ion moves under the influence of an electric field. This link connects the physical behavior of ions in solution to the chemical processes that occur during electrochemical...
Transcellular Transport of Solutes01:23

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...

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Related Experiment Video

Updated: Jul 4, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Quantifying intermittent transport in cell cytoplasm.

Thibault Lagache1, David Holcman

  • 1Department of Biology, Ecole Normale SupĂ©rieure, 46 rue d'Ulm 75005 Paris, France.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 4, 2008
PubMed
Summary
This summary is machine-generated.

Viruses utilize active cellular transport for nuclear entry. This study models intermittent motion and estimates the mean time for viruses to reach nuclear pores, considering microtubule interactions and degradation.

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Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Area of Science:

  • Cellular Biology
  • Biophysics
  • Virology

Background:

  • Active cellular transport is crucial for cellular functions and viral pathogenesis.
  • Viruses exploit intracellular transport pathways, particularly microtubule networks, to reach target sites like the nucleus.
  • Intracellular particle motion often exhibits intermittent dynamics, alternating between Brownian and directed movement.

Purpose of the Study:

  • To estimate the mean time for a particle, such as a virus, to attach to a microtubule network.
  • To develop a coarse-grained model for intermittent motion in different geometries.
  • To refine estimations of viral nuclear entry probability and mean time, incorporating cytoplasmic degradation.

Main Methods:

  • Modeling intermittent dynamics of particle motion.
  • Estimating attachment time to microtubule networks.
  • Developing coarse-grained equations for radial and cylindrical geometries.
  • Incorporating cytoplasmic degradation into transport models.

Main Results:

  • A computational framework to estimate the mean time for particle attachment to microtubule networks.
  • Coarse-grained equations describing intermittent motion in various cellular geometries.
  • Refined asymptotic estimations for viral nuclear entry probability and mean time, accounting for degradation.

Conclusions:

  • Understanding intermittent transport dynamics is key to deciphering viral nuclear import mechanisms.
  • The developed models provide quantitative insights into virus-host interactions and intracellular transport.
  • This research contributes to the understanding of viral spread and potential therapeutic targets.