Related Experiment Video
Updated: Jul 22, 2026

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
Published on: October 28, 2022
[Pulmonary silicosis and glomerular nephropathy. Apropos of 1 case]
D Pouthier1, P Duhoux, B Van Damme
1Département de Néphrologie, Centre Hospitalier de Luxembourg.
Abstract:
A 43-year-old stone cutter with 13 years of exposure to silica developed a pulmonary silicosis and a glomerulonephritis with moderate renal failure. Renal biopsy demonstrated in light microscopy a segmental and focal mesangial proliferation and in electron microscopy distinct alterations of the proximal tubular cells. Renal histology suggest silica may play a part in the pathogenesis of renal damage. Clinicians should therefore include silica exposure in the differential diagnosis of unexplained glomerulonephritis.
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