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Updated: Jul 4, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

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Published on: January 16, 2019

Sequence variants in host cell factor C1 are associated with Ménière's disease

Jeffrey T Vrabec1, Liqian Liu, Bingshan Li

  • 1Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, U.S.A. jvrabec@bcm.edu

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|June 4, 2008
PubMed
Abstract

Insights

Genetic factors may influence Ménière

Area of Science:

  • Genetics
  • Otolaryngology
  • Molecular Biology

Background:

  • The etiology of Ménière's disease (MD) remains unknown.
  • Familial cases and higher prevalence in Caucasians suggest a potential genetic link.
  • Autosomal dominant inheritance patterns have been observed in some families.

Purpose of the Study:

  • To investigate the genetic basis of Ménière's disease.
  • To identify specific genes and genetic variations associated with MD development.

Main Methods:

  • A case-control association study was conducted.
  • Candidate genes were analyzed in patients with MD and control individuals.
  • Single-nucleotide polymorphisms (SNPs) were examined.

Main Results:

  • Specific SNPs in the host cell factor C1 (HCFCI) gene were more prevalent in MD patients.
  • The major allele of rs2266886 showed a significant association with MD.
  • The minor allele at rs2266886 was associated with a reduced risk of developing MD (OR=0.26).

Conclusions:

  • The minor alleles of identified SNPs in HCFCI may confer protection against MD.
  • Individuals with these protective alleles appear to have a reduced risk of developing the disease.
  • Further research is needed to understand the functional impact of these HCFCI SNPs and their interaction with viral proteins like VP16.

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