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Related Concept Videos

Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jul 4, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

Skeletal muscle dressed in SOCs.

Dong Min Shin, Shmuel Muallem

    Nature Cell Biology
    |June 4, 2008
    PubMed
    Summary

    Store-operated calcium channels (SOCs) are crucial for skeletal muscle function. Stromal interaction molecule 1 (STIM1) and Orai1 are key regulators of these channels in muscle development and physiological processes.

    Area of Science:

    • Cellular Biology
    • Physiology
    • Molecular Biology

    Background:

    • Store-operated calcium channels (SOCs) regulate intracellular calcium (Ca2+) levels.
    • Stromal interaction molecule 1 (STIM1) acts as the endoplasmic reticulum (ER) Ca2+ sensor.
    • Orai and TRPC channels form the pore-forming subunits of SOCs.

    Discussion:

    • Orai1 and STIM1 are highly expressed in skeletal muscle tissue.
    • SOCs play a significant role in skeletal muscle development.
    • These channels are integral to skeletal muscle function and homeostasis.

    Key Insights:

    • STIM1 senses Ca2+ depletion in the ER.
    • STIM1 interacts with Orai1 and TRPC channels to mediate Ca2+ influx.
    • The STIM1-Orai1/TRPC pathway is critical for skeletal muscle physiology.

    More Related Videos

    Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues
    09:30

    Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

    Published on: February 18, 2021

    Related Experiment Videos

    Last Updated: Jul 4, 2026

    Skeletal Muscle Gender Dimorphism from Proteomics
    09:29

    Skeletal Muscle Gender Dimorphism from Proteomics

    Published on: December 14, 2011

    Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues
    09:30

    Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues

    Published on: February 18, 2021

    Outlook:

    • Further research into SOCs in skeletal muscle could reveal therapeutic targets.
    • Understanding SOC function may elucidate mechanisms of muscle diseases.
    • Investigating STIM1 and Orai1 roles offers insights into calcium signaling in excitable cells.