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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jul 4, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Molecular approaches to sarcoma therapy.

R J Olsen1, S R Tarantolo, S H Hinrichs

  • 1Department of Pathology and Microbiology University of Nebraska Medical Center Omaha NE 69198-6495 USA.

Sarcoma
|June 4, 2008
PubMed
Summary

Gene-based therapies offer new hope for aggressive soft tissue sarcomas. Targeting specific molecular mechanisms, like chimeric proteins, may overcome limitations of conventional treatments for better patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Soft tissue sarcomas are aggressive tumors with poor prognoses.
  • Conventional therapies often fail to achieve curative outcomes.
  • Sarcomas characteristically feature unique chromosomal translocations leading to chimeric proteins.

Purpose of the Study:

  • To review gene-based therapeutic approaches targeting specific molecular mechanisms in sarcomagenesis.
  • To present the strategy and significance of translational studies in six distinct areas.
  • To discuss the potential for improving sarcoma patient outcomes and associated challenges.

Main Methods:

  • Review of published translational studies.
  • Focus on six key therapeutic strategies targeting sarcomagenesis.

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

  • Analysis of molecular mechanisms driving sarcoma development and progression.

    • Main Results:

    • Six distinct therapeutic strategies are presented: disrupting chimeric transcription factors, inhibiting growth-promoting modifications, restoring tumor suppressor function, interfering with angiogenesis, inducing apoptosis, and introducing toxic gene products.
    • The success of tyrosine kinase inhibitors like STI571 supports targeted therapies.
    • These approaches aim to counteract neoplastic processes by eliminating clonal aberrations.

    Conclusions:

    • Gene-based therapies targeting specific molecular mechanisms hold significant potential for improving soft tissue sarcoma treatment.
    • Overcoming conceptual obstacles is crucial for translating these strategies into clinical success.
    • Targeted approaches offer a promising alternative to conventional treatments for aggressive sarcomas.