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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

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Related Experiment Video

Updated: Jul 4, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

[Putative hepatitis C virus cell receptors].

T E Farafonova, L V Olenina, E F Kolesanova

    Biomeditsinskaia Khimiia
    |June 5, 2008
    PubMed
    Summary

    Blocking hepatitis C virus (HCV) entry into host cells is key to preventing infection. Identifying host cell receptors and viral molecules involved in HCV binding and cell entry is crucial for developing antiviral therapies.

    Area of Science:

    • Virology
    • Cell Biology
    • Immunology

    Context:

    • Viral entry into host cells is the critical first step in infection.
    • Understanding host-pathogen interactions at the molecular level is essential for developing effective treatments.
    • The hepatitis C virus (HCV) lifecycle begins with its entry into susceptible host cells.

    Purpose:

    • To review and identify host cell outer membrane molecules involved in hepatitis C virus (HCV) binding.
    • To discuss the role of these molecules as potential receptors and coreceptors for HCV.
    • To explore strategies for blocking viral entry to prevent HCV infection.

    Summary:

    • This review focuses on identifying host cell membrane molecules that mediate hepatitis C virus (HCV) binding and internalization.

    More Related Videos

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    13:04

    A Protocol for Analyzing Hepatitis C Virus Replication

    Published on: June 26, 2014

    Related Experiment Videos

    Last Updated: Jul 4, 2026

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
    09:02

    Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

    Published on: June 5, 2020

    Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
    16:49

    Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

    Published on: July 16, 2012

    A Protocol for Analyzing Hepatitis C Virus Replication
    13:04

    A Protocol for Analyzing Hepatitis C Virus Replication

    Published on: June 26, 2014

  • It examines the function of these molecules as receptors and coreceptors, crucial for initiating HCV infection.
  • Understanding these interactions is vital for developing targeted antiviral interventions.

    • Impact:

    • Provides a comprehensive overview of host factors essential for HCV entry.
    • Highlights potential therapeutic targets for blocking HCV infection.
    • Facilitates the development of novel antiviral strategies aimed at preventing viral cell penetration.