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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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[Von Willebrand disease]

P Smejkal1, M Matýsková, M Penka

  • 1Oddelení klinické hematologie FN Brno. psmejkal@fnbrno.cz

Vnitrni Lekarstvi
|June 5, 2008
PubMed

Von Willebrand disease is the most spread hereditary bleeding disorder with prevalence up to the 1% in the population. Haemorrhagic symptoms are various intensity, mostly not severe. A large part of affected patients do not come to see a doctor. However these patients are potentially endangered by a serious haemorrhage after a trauma, surgery or during another illness. The estimated number of patients with von Willebrand disease is 1,500-3,500 per 1,000,000 of population; the number of persons with symptomatic von Willebrand disease was estimated to be at least 100 per million. This disease deserves attention not only by haematologists but other physicians too. In our communication we present short overview about von Willebrand disease: there are briefly described pathophysiology, classification, diagnosis and treatment of this illness.

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