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Updated: Jul 4, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Medial necrosis due to sirolimus-eluting stent implantation in human coronary artery
Katsumi Inoue1, Kazuaki Mitsudo, Masakiyo Nobuyoshi
1Department of Cardiology, Kurashiki Central Hospital, Miwa, Kurashiki 710-8602, Japan. takenaka@m.kufm.kagoshima-u.ac.jp <takenaka@m.kufm.kagoshima-u.ac.jp>
Abstract:
We report an autopsy case showing medial necrosis at the segment of sirolimus-eluting stent implantation. These findings indicate that cytotoxic effects of sirolimus can induce late-acquired incomplete stent apposition and/or aneurysmal changes after stenting in human coronary arteries.
Insights
Sirolimus-eluting stents can cause artery damage, leading to incomplete stent apposition and aneurysms. This autopsy case highlights the cytotoxic effects of sirolimus in coronary arteries.
Area of Science:
- Cardiovascular pathology
- Interventional cardiology
- Pharmacology
Background:
- Coronary artery stenting is a common procedure.
- Sirolimus-eluting stents (SES) are widely used to prevent restenosis.
- Potential long-term complications of SES require further investigation.
Observation:
- An autopsy case revealed medial necrosis at the site of sirolimus-eluting stent implantation.
- Histopathological examination identified specific changes in the coronary artery wall.
Findings:
- Sirolimus-eluting stents demonstrated cytotoxic effects on the arterial wall.
- These effects were associated with late-acquired incomplete stent apposition.
- Aneurysmal changes were observed in the stented arterial segments.
Implications:
- The findings suggest a mechanism for late stent malapposition and aneurysm formation linked to sirolimus.
- Understanding these cytotoxic effects is crucial for evaluating the long-term safety of sirolimus-eluting stents.
- Further research is warranted to explore preventative strategies and alternative stent designs.
