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Related Experiment Video

Updated: Jul 4, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Tumor detection using folate receptor-targeted imaging agents.

Emanuela I Sega1, Philip S Low

  • 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. esega@stanford.edu

Cancer Metastasis Reviews
|June 5, 2008
PubMed
Summary
This summary is machine-generated.

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Folate receptors (FR) are over-expressed in many cancers. Targeting these FR-expressing tumors with folic acid-linked imaging agents helps diagnose and treat cancers more effectively.

Area of Science:

  • Oncology
  • Molecular Imaging
  • Drug Development

Background:

  • Folate receptors (FR) are significantly over-expressed on various human cancers, including breast, ovarian, lung, and brain cancers.
  • This specific expression pattern presents a unique opportunity for targeted cancer therapies and diagnostics.
  • Most healthy tissues exhibit minimal FR expression, allowing for tumor-specific targeting.

Purpose of the Study:

  • To review recent advancements in utilizing folic acid for targeting diagnostic and therapeutic agents to FR-expressing tumors.
  • To highlight the application of folic acid in developing novel imaging agents for improved cancer detection.
  • To discuss the role of FR-targeted imaging in patient selection for folate-targeted therapies.

Main Methods:

  • Focuses on recent literature and research in the field of folate receptor-targeted oncology.

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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

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Last Updated: Jul 4, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

  • Reviews the development and application of various imaging modalities, including PET, SPECT (gamma-emitters), MRI, and fluorescence imaging.
  • Examines the use of folic acid as a targeting ligand for these imaging agents.

    • Main Results:

    • Folic acid effectively targets imaging agents to FR-positive tumors, enhancing diagnostic specificity and sensitivity.
    • Advancements include PET agents, gamma-emitters, MRI contrast agents, and fluorescent dyes for FR(+) cancer imaging.
    • FR-targeted imaging is crucial for identifying patients who will benefit from FR-targeted therapies.

    Conclusions:

    • Folic acid-targeted imaging agents offer a promising strategy for the precise diagnosis and visualization of FR-expressing cancers.
    • This approach improves the selection of patients for targeted therapies, maximizing treatment efficacy.
    • Continued research in this area holds potential for significant improvements in cancer care.