Effect of loracarbef on the normal oropharyngeal and intestinal microflora

20 healthy volunteers received loracarbef capsules 200 mg b.i.d. for 7 days. Saliva and stool specimens were taken before loracarbef administration and on the 2nd, 5th, and 7th day during the administration period, and again 2, 5 and 9 days after withdrawal of the antibiotic to study the effect of loracarbef on the normal microflora. The concentrations of loracarbef in serum, saliva and faeces were determined by an agar diffusion method. The mean serum peak concentration attained after 1 h was 6.8 mg/l and the saliva concentrations were in the range 0-0.9 mg/l. The loracarbef concentrations in faeces ranged from 0 to 0.9 mg/kg. The changes in the the oropharyngeal microflora were minor and only bacteroides rods were affected. In the intestinal aerobic microflora, the number of enterococci and streptococci slightly increased while staphylococci, micrococci, corynebacteria, bacillus and enterobacteria were not affected. The number of bifidobacteria and eubacteria in the anaerobic microflora decreased while no other bacterial groups were affected. One week after withdrawal of loracarbef, both the oropharyngeal and intestinal microflora had returned to normal. No new colonizing loracarbef resistant microorganisms were observed during the investigation period.