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Acute myocardial infarction in hospitalized patients with community-acquired pneumonia

Julio Ramirez1, Stefano Aliberti, Mehdi Mirsaeidi

  • 1Divisions of Infectious Diseases, University of Louisville and Veterans Administration, Louisville, Kentucky 40202, USA. j.ramirez@louisville.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 7, 2008
PubMed
Abstract

Insights

Acute myocardial infarction (AMI) is common in patients with severe community-acquired pneumonia (CAP). AMI should be considered when hospitalized CAP patients experience clinical failure, indicating a significant association.

Area of Science:

  • Cardiology
  • Pulmonology
  • Infectious Diseases

Background:

  • Epidemiological studies suggest a link between respiratory infections and acute myocardial infarction (AMI).
  • Recent data indicate an association between AMI and pneumococcal community-acquired pneumonia (CAP) in hospitalized patients.

Purpose of the Study:

  • To investigate the association between AMI and pneumonia severity at hospitalization.
  • To examine the association between AMI and clinical failure during hospitalization among CAP patients.

Main Methods:

  • Observational, retrospective study of 500 hospitalized CAP patients.
  • Severe CAP defined as ICU admission; clinical failure as respiratory failure or shock.
  • Propensity-adjusted models used to analyze associations between AMI, pneumonia severity, and clinical failure.

Main Results:

  • AMI was present in 15% of severe CAP patients at admission and 20% of those with clinical failure.
  • Significant associations were found between AMI and pneumonia severity index (P = .05).
  • Significant association was found between AMI and clinical failure (P = .04).

Conclusions:

  • Combined diagnosis of CAP and AMI is common in hospitalized patients with severe CAP.
  • AMI should be considered in hospitalized CAP patients experiencing clinical failure.

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