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Prenatal and neonatal risk factors for sleep disordered breathing in school-aged children born preterm

Anna Maria Hibbs1, Nathan L Johnson, Carol L Rosen

  • 1Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106-6010, USA. annamaria.hibbs@case.edu

The Journal of Pediatrics
|June 7, 2008
PubMed

Insights

Mild preeclampsia and single motherhood are linked to childhood sleep disordered breathing (SDB) in preterm infants. These factors, not traditional neonatal severity markers, may predict SDB risk in this vulnerable population.

Area of Science:

  • Neonatal Health
  • Pediatric Sleep Medicine
  • Neurodevelopmental Outcomes

Background:

  • Preterm infants exhibit heightened vulnerability to sleep disordered breathing (SDB) and associated neurocognitive deficits.
  • Previous research highlights the long-term risks of SDB in children born prematurely.

Purpose of the Study:

  • To identify neonatal medical history components associated with childhood SDB in prematurely born children.
  • To explore perinatal and neonatal risk factors for SDB development in school-aged preterm children.

Main Methods:

  • Analysis of 383 preterm children (<37 weeks gestational age) from the Cleveland Children's Sleep and Health Study.
  • Logistic regression used to assess associations between neonatal risk factors and SDB identified via sleep studies at ages 8-11 years.

Main Results:

  • 7.3% of preterm children (28/383) were diagnosed with SDB.
  • Mild maternal preeclampsia and single motherhood were significantly associated with childhood SDB.
  • No significant association found between traditional neonatal illness severity markers (e.g., gestational age, birth weight, BPD) and childhood SDB.

Conclusions:

  • Identifies prenatal and neonatal factors associated with increased SDB risk in preterm infants.
  • Highlights the critical role of in utero factors, such as mild preeclampsia, in neurorespiratory development and SDB risk.
Abstract

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