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Updated: Jul 4, 2026
09:09
Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
Published on: February 24, 2021
Respiratory allergy to lipid transfer protein
Franco Borghesan1, Gianni Mistrello, Daniela Roncarolo
1Dipartimento di Medicina di Laboratorio, Padova, Italy.
International Archives of Allergy and Immunology
|June 7, 2008
Summary
Airborne sensitization to lipid transfer protein (LTP) allergy may occur through respiratory exposure to airborne food particles, potentially explaining its higher prevalence in Mediterranean regions. This airborne route may precede the development of food allergies.
Area of Science:
- Food allergy research
- Immunology
- Environmental health
Background:
- Lipid transfer protein (LTP) allergy is common in Mediterranean areas but infrequent in Northern Europe.
- The precise reasons for this geographical disparity in LTP allergy remain unclear.
Observation:
- A case study of a 21-year-old woman in Southern Italy presented with severe perennial rhinitis after working in a fruit storehouse.
- Symptoms improved upon leaving the workplace and recurred upon return, suggesting an environmental trigger.
- The patient subsequently developed severe food allergies to multiple fruits and nuts.
Findings:
- Nasal challenge with peach peel extract induced acute respiratory symptoms, confirming sensitivity.
- Immunoblot analysis revealed IgE reactivity solely against LTP in peach peel extract.
- In vivo and in vitro tests confirmed sensitization to LTP.
Implications:
- Sensitization to LTP can occur via the respiratory tract through inhalation of airborne food particles.
- This airborne sensitization may precede the development of clinical food allergies.
- This mechanism could explain the geographical distribution of LTP allergy, particularly in regions with high peach consumption and cultivation.
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