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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[The study on the preparation and spectroscopic properties of hydroxypropyl-beta-cyclodextrin/glipizide inclusion
Yi-Min Zhang1, Xiao Li, Cong-Shan Sun
1Key Laboratory for Green Chemical Technology, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. zhangym001@263.net
Abstract:
The interaction of glipizide and hydroxypropyl-pcyclodextrin was investigated in the present paper. The stability constant and molar ratio of glipizide and hydroxypropyl-beta-cyclodextrin was calculated from the phase soluility diagram. The solid state inclusion complex of hydroxypropyl-beta-cyclodextrin/glipizide prepared by neutralization method was characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). It was found that the phase solubility diagram of the HP-beta-CD solution showed a typical AL-type, suggesting the formation of a soluble complex of 1 : 1 molar ratio, and the stability constant was 359 L x mol(-1) at 25 degrees C. The spectra of IR, thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the glipizide and hydroxypropyl-beta-cyclodextrin/glipizide physical mixture, and indicated that hydroxypropyl-beta-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic. The experiment of solubility of inclusion complex indicated that the solubility of inclusion complex increased 25-fold.
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