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Transgenic Organisms

Transgenic Organisms

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Jan 8, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Transgenic models in allergic responses.

Michael Hausding¹, Kerstin Sauer, Joachim H Maxeiner

¹Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany.

Current Drug Targets

|June 10, 2008

Summary

This summary is machine-generated.

Murine models reveal key T cell transcription factors like T-bet and GATA-3 crucial for allergic asthma. These models advance understanding of immune responses and therapies for asthma.

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Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Immunology
Molecular Biology
Genetics

Background:

Immune responses involve antigen presentation to T cells.
T helper cell differentiation is regulated by specific transcription factors (T-bet, c-maf, GATA-3, Foxp3, RORgammaT).
These factors are implicated in the pathogenesis of allergic asthma.

Purpose of the Study:

To investigate the role of T cell transcription factors in allergic asthma using transgenic murine models.
To understand the contribution of specific genes and cytokines (IL-18, TGF-beta receptor II) to asthma pathogenesis.
To establish reliable models for preclinical evaluation of asthma therapies.

Main Methods:

Generation of germline and tissue-specific transgenic mice (Clara Cell or CD2 promoter).
Utilized Cre-lox systems for conditional gene expression.
Created transgenic lines overexpressing IL-18 and analyzed dominant-negative TGF-beta receptor II mutants.

Main Results:

Identified T cell transcription factors T-bet, c-maf, and GATA-3 as critical in asthma.
Transgenic and knockout models provided insights into human asthma.
Established models for studying T cell memory and airway remodeling in chronic asthma.

Conclusions:

Transgenic murine models are essential tools for dissecting immune responses in allergic asthma.
These models facilitate the understanding of T cell transcription factor function and cytokine roles.
The developed models support preclinical testing of novel asthma therapeutics and antibodies.