Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

Energy Balance

Energy Balance

The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Assessing metabolic flexibility in adults under physiological conditions: Effects of dietary fat and exercise in whole-room calorimetry.

Physiological reports·2026

Same author

Frequent vs single active bouts differentially affect movement behavior and energy balance in adults with overweight/obesity.

medRxiv : the preprint server for health sciences·2026

Same author

Effects of 4:3 Intermittent Fasting on Eating Behaviors and Appetite Hormones: A Secondary Analysis of a 12-Month Behavioral Weight Loss Intervention.

Nutrients·2025

Same author

Effect of physical activity on changes in weight and aerobic capacity during an 18-month behavioral weight loss intervention.

The international journal of behavioral nutrition and physical activity·2025

Same author

The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial.

Annals of internal medicine·2025

Same author

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol.

Journal of applied physiology (Bethesda, Md. : 1985)·2024

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Update on obesity.

Daniel H Bessesen¹

¹Division of Endocrinology, Denver Health Medical Center, and University of Colorado School of Medicine, Aurora, CO 80045, USA. daniel.bessesen@uchsc.edu

The Journal of Clinical Endocrinology and Metabolism

|June 10, 2008

Summary

This summary is machine-generated.

Endocrinologists play a key role in managing obesity, a growing health concern. While new insights into obesity mechanisms emerge, effective treatments like diet, exercise, and surgery show promise for future patient care.

More Related Videos

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jul 4, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Area of Science:

Metabolic Diseases
Obesity Research
Endocrinology

Background:

Obesity prevalence is plateauing, but severe obesity and childhood overweight are increasing, indicating a future rise in related illnesses.
Novel obesity mechanisms include genetic factors, gut microbiota, and social network influences.
Endocrinologists are uniquely positioned to lead obesity management strategies.

Purpose of the Study:

To review current understanding and management of obesity.
To highlight recent advancements in obesity research and treatment options.
To emphasize the role of endocrinologists in addressing the growing burden of obesity.

Main Methods:

Review of recent epidemiological data on obesity prevalence.
Analysis of emerging research on obesity mechanisms (genetics, microbiome, social factors).
Evaluation of current and emerging treatment modalities including dietary, physical activity, pharmacotherapy, and surgical interventions.

Main Results:

Dietary adherence is crucial for modest weight loss; physical activity is key for maintenance.
Pharmacotherapy options are limited but evolving, with several promising drug targets.
Surgical treatment shows significant benefits, including reduced mortality and improved diabetes outcomes, though optimal approaches require further study.

Conclusions:

Obesity management requires a multifaceted approach, leveraging new scientific insights.
Surgical interventions offer substantial benefits for severe obesity and associated comorbidities.
Continued research is vital for developing more effective future obesity management strategies.