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Updated: Jul 4, 2026
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Cancer Borealis Stomatogastric Nervous System Dissection
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[Functional and morphologic organization of stomach vegetative innervation]
Uspekhi Fiziologicheskikh Nauk
|June 11, 2008
Summary
The sympathetic and vagal nerves influence stomach motor activity via serotonin pathways. Vagal nerve stimulation causes serotonin release from EC-cells, impacting stomach function, especially in older individuals.
Area of Science:
- Neurogastroenterology
- Autonomic Nervous System Physiology
- Serotonergic Signaling
Context:
- The stomach's motor functions are regulated by complex neural networks.
- Vegetative innervation, including sympathetic and vagal nerves, plays a crucial role.
- Serotonin (5-HT) is increasingly recognized for its involvement in gastrointestinal motility.
Purpose:
- To investigate the functional and morphological organization of stomach vegetative innervation.
- To elucidate the role of sympathetic and vagal nerves in modulating stomach motor activity.
- To identify the specific neural pathways and cellular mechanisms involved.
Summary:
- Sympathetic nerve stimulation potentiates vagal nerve-induced motor activity in different stomach regions.
- Preganglionic serotoninergic fibers transmit excitation to ganglionic serotoninergic neurons, mediating this effect.
- Vagal nerve stimulation leads to degranulation of enterochromaffin (EC) cells expressing 5-HT3,4-receptors, and reduces EC-cell volume in aged subjects.
Impact:
- Provides novel insights into the neuro-enteric control of gastric motility.
- Highlights the critical role of serotoninergic pathways in autonomic regulation of the stomach.
- Suggests age-related changes in neuro-glandular interactions within the stomach's innervation.
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