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Updated: Jul 4, 2026
07:46
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
[Ischemic tolerance (preconditioning) of the brain]
Anesteziologiia I Reanimatologiia
|June 11, 2008
Summary
Ischemic tolerance, or preconditioning, uses brief ischemia to activate protective mechanisms against future severe episodes. This review explores its potential for brain protection, noting evidence in humans.
Area of Science:
- Neuroscience
- Physiology
- Cell Biology
Context:
- Ischemic tolerance, also known as preconditioning, involves brief, sub-lethal ischemic events.
- These events trigger endogenous protective mechanisms within cells and tissues.
Purpose:
- To review and analyze the existing information on ischemic preconditioning.
- To evaluate its potential application for brain protection.
Summary:
- The review examines experimental models, temporal dynamics, cross-tolerance, genomic responses, and underlying mechanisms of ischemic preconditioning.
- Evidence suggests that ischemic preconditioning occurs in humans.
Impact:
- Provides a comprehensive overview of ischemic preconditioning research.
- Highlights the potential of preconditioning strategies for neuroprotection and mitigating ischemic injury.
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