[Systemic metastases of malignant gliomas]
Maryam Fourtassi1, Dimitri Psimaras, François Ducray
1Service de neurologie Mazarin, Groupe hospitalier Pitié-Salpêtrière, 83, bd de l'Hôpital, 75013 Paris. fourtmary@yahoo.fr
Abstract:
Despite malignant gliomas are highly invasive tumors, extracranial metastatases are extremely rare. We report herein four cases (two glioblastomas, a gliosarcoma and an anaplastic oligodendroglioma) with systemic dissemination occurring 3 to 13 months after surgery. Metastases involved liver, lung, kidney, bone and bone marrow. Survival time after metastatic dissemination ranged from 2 to 5 months for glioblastomas and gliosarcoma. Metastases from the anaplastic oligodendroglioma which displayed 1p and 19q chromosome codeletion, responded to chemotherapy and the patient survived 8 months.
