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Related Experiment Video

Updated: Jul 4, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

Endogenous digitalis: pathophysiologic roles and therapeutic applications.

Alexei Y Bagrov¹, Joseph I Shapiro

¹Hypertension Unit at Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore 21224, MD, USA. bagrova@mail.nih.gov

Nature Clinical Practice. Nephrology

|June 11, 2008

Summary

Endogenous cardiotonic steroids, like ouabain, play key roles in cardiovascular health and disease. Research highlights their involvement in essential hypertension, heart failure, and kidney disease, paving the way for new therapies.

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Last Updated: Jul 4, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System

Published on: May 22, 2018

Area of Science:

Physiology
Endocrinology
Cardiovascular Medicine

Background:

Endogenous digitalis-like factors, or cardiotonic steroids, have been studied for decades.
Ouabain and marinobufagenin are identified human cardiotonic steroids signaling via the sodium/potassium-transporting ATPase.
Their roles extend beyond renal sodium transport to cell growth, apoptosis, and fibrosis.

Purpose of the Study:

To review the role of endogenous cardiotonic steroids in major cardiovascular and renal diseases.
To explore potential therapeutic strategies based on cardiotonic steroid function.

Main Methods:

Literature review focusing on endogenous cardiotonic steroids.
Analysis of their involvement in pathophysiology of hypertension, heart failure, ESRD, and pre-eclampsia.

Main Results:

Cardiotonic steroids are implicated in essential hypertension, congestive heart failure, end-stage renal disease, and pre-eclampsia.
Established effector mechanisms involve the sodium/potassium-transporting ATPase.

Conclusions:

Endogenous cardiotonic steroids are significant factors in cardiovascular and renal pathophysiology.
Understanding their regulation and actions offers novel therapeutic avenues.