Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nanoscale optofluidic sensor arrays.

Sudeep Mandal1, David Erickson

  • 1School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA.

Optics Express
|June 11, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the needs of technical developers and stakeholders in point-of-care technology development: a qualitative study.

BMJ open·2026
Same author

Integrated triplex LFIA platform for decentralized molecular subtyping of breast cancer.

RSC advances·2026
Same author

Saliva as a Matrix for Primary Care: Feasibility and Scoping of Its Use for Assessment of Nutrition and Inflammation.

Advances in nutrition (Bethesda, Md.)·2026
Same author

Artificial Intelligence-Based Diagnosis of Kaposi Sarcoma Using Digital Photographs in Dark-Skinned Patients in Uganda.

JCO global oncology·2026
Same author

Loop-Mediated Isothermal Amplification Enables Reliable Kaposi Sarcoma Diagnosis Across Time and Sites in East Africa.

Journal of medical virology·2025
Same author

Comparison of two nanomaterial labels for detection of SARS-CoV-2 nucleocapsid antigen to improve analytical performance of lateral flow immunoassays.

RSC advances·2025
Same journal

Long-term stabilization of intensity-difference squeezing from four-wave mixing in rubidium vapor.

Optics express·2026
Same journal

Robust 3D topography measurement of large-range high-aspect-ratio structures based on dual-domain statistical filtering in SD-OCT.

Optics express·2026
Same journal

Broadband transmissive terahertz metasurface for simultaneous quad-mode OAM multiplexing.

Optics express·2026
Same journal

Leveraging two-dimensional materials for high-sensitivity optical sensors: quasi-bound states in the continuum within hybrid metasurfaces.

Optics express·2026
Same journal

Resolution investigation for dual-spherical-wave optical scanning holographic microscopy: methods and performance.

Optics express·2026
Same journal

Robustness of parallel subnetwork-filtered diffractive deep neural networks.

Optics express·2026
See all related articles

We developed Nanoscale Optofluidic Sensor Arrays (NOSAs) for label-free detection of biomolecular interactions. This technology enables highly sensitive, parallel measurements in aqueous solutions with attogram-level detection limits.

Area of Science:

  • Optofluidics
  • Nanotechnology
  • Biomolecular Interaction Analysis

Background:

  • Label-free detection is crucial for real-time biomolecular interaction studies.
  • Existing methods often face limitations in sensitivity or parallelism.
  • Optofluidic architectures offer potential for enhanced sensing capabilities.

Purpose of the Study:

  • To introduce Nanoscale Optofluidic Sensor Arrays (NOSAs) for highly parallel, label-free biomolecular detection.
  • To demonstrate the potential for attogram-level mass detection limits.
  • To validate the refractive index sensitivity of the proposed architecture.

Main Methods:

  • Utilizing arrays of 1D photonic crystal resonators coupled to a bus waveguide.
  • Leveraging shifts in resonant peaks due to changes in local refractive index.

Related Experiment Videos

  • Confining biomolecular binding to the resonator's sensing region.

    • Main Results:

    • Numerical simulations predict attogram (ag) limits of detection.
    • Experimental validation achieved a refractive index (RI) detection limit of 7 x 10(-5).
    • The architecture confines the probed surface area, enabling low mass detection limits.

    Conclusions:

    • NOSAs provide a promising platform for sensitive, parallel, label-free biomolecular detection.
    • The architecture's design facilitates high sensitivity by minimizing the probed volume.
    • This technology has significant potential for applications in diagnostics and drug discovery.