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Related Experiment Video

Updated: Jun 12, 2026

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
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Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Resolution investigation for dual-spherical-wave optical scanning holographic microscopy: methods and performance.

Xiongchun Lin, Jilu Duan, Pengtao Li

    Optics Express
    |June 11, 2026
    PubMed
    Summary

    This study introduces a novel optical scanning holographic microscopy system that achieves higher resolution and faster recording speeds. The new system surpasses conventional limits for imaging biological and nanoscale samples.

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    Last Updated: Jun 12, 2026

    Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization
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    Published on: July 5, 2016

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    Published on: February 12, 2014

    Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects
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    Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

    Published on: February 8, 2014

    Area of Science:

    • Optics and Photonics
    • Microscopy
    • Biomedical Imaging

    Background:

    • Conventional optical scanning holographic microscopy faces limitations in recording speed and spatial resolution.
    • Existing systems struggle to achieve high-fidelity imaging of dynamic or nanoscale specimens.

    Purpose of the Study:

    • To develop an advanced optical scanning holographic microscopy system with enhanced spatial resolution and recording speed.
    • To investigate the impact of spherical-wave curvature on imaging resolution.

    Main Methods:

    • A dual-spherical-wave illumination scheme utilizing X-Y galvanometric scanning and an afocal 4f-like relay was implemented.
    • A scan lens and tube lens were integrated into the afocal relay to maintain Fresnel zone plate integrity.
    • Spherical-wave curvature was adjusted to optimize lateral resolution.

    Main Results:

    • Achieved a lateral resolution of 312 nm at 532 nm, exceeding the objective's Rayleigh limit of 432 nm.
    • Demonstrated high-contrast imaging of human red blood cells.
    • Successfully imaged submicron transparent plastic particles.

    Conclusions:

    • The proposed optical scanning holographic microscopy system offers superior resolution and speed.
    • The system shows significant potential for high-speed, high-resolution volumetric imaging of biological and micro-/nanoscale specimens.