Two primary seminomas in a patient with polyorchidism

Area of Science:

• Urology
• Oncology
• Pathology

Background:

• Cryptorchidism (undescended testes) is a known risk factor for testicular germ cell tumors.
• Polyorchidism (more than two testes) is an extremely rare congenital anomaly, often asymptomatic and incidentally discovered.
• The association between polyorchidism and malignancy is not well-established, with limited case reports.

Purpose of the Study:

• To report a rare case of polyorchidism associated with an abdominal seminoma in a patient with a history of cryptorchidism and prior orchiectomy.
• To investigate the potential link between polyorchidism and the development of primary testicular tumors.
• To suggest a clinical approach for patients presenting with cryptorchidism.

Main Methods:

• Case report detailing clinical, radiographic, and pathological findings.
• Review of patient history including childhood cryptorchidism and previous seminoma treatment.
• Pathological examination of the abdominal tumor and surrounding tissues.

Main Results:

• A 28-year-old male presented with a right-sided abdominal seminoma.
• The patient had a history of childhood cryptorchidism and a prior left-sided seminoma treated with orchiectomy.
• Pathological analysis confirmed a classic seminoma with adjacent epididymal remnants, suggesting a supernumerary testis.

Conclusions:

• This case highlights the association between polyorchidism and testicular seminoma.
• Patients with cryptorchidism should be evaluated for polyorchidism, as supernumerary testes may harbor primary tumors.
• Early detection and management strategies may be warranted for individuals with polyorchidism and a history of testicular germ cell tumors.