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Published on: July 5, 2021
Preoperative subtyping of meningiomas by perfusion MR imaging
Hao Zhang1, Lars A Rödiger, Tianzhen Shen
1Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. zhanghao021@gmail.com
Introduction:
This paper aims to evaluate the value of perfusion magnetic resonance (MR) imaging in the preoperative subtyping of meningiomas by analyzing the relative cerebral blood volume (rCBV) of three benign subtypes and anaplastic meningiomas separately.
Materials And Methods:
Thirty-seven meningiomas with peritumoral edema (15 meningothelial, ten fibrous, four angiomatous, and eight anaplastic) underwent perfusion MR imaging by using a gradient echo echo-planar sequence. The maximal rCBV (compared with contralateral normal white matter) in both tumoral parenchyma and peritumoral edema of each tumor was measured. The mean rCBVs of each two histological subtypes were compared using one-way analysis of variance and least significant difference tests. A p value less than 0.05 indicated a statistically significant difference.
Results:
The mean rCBV of meningothelial, fibrous, angiomatous, and anaplastic meningiomas in tumoral parenchyma were 6.93 +/- 3.75, 5.61 +/- 4.03, 11.86 +/- 1.93, and 5.89 +/- 3.85, respectively, and in the peritumoral edema 0.87 +/- 0.62, 1.38 +/- 1.44, 0.87 +/- 0.30, and 3.28 +/- 1.39, respectively. The mean rCBV in tumoral parenchyma of angiomatous meningiomas and in the peritumoral edema of anaplastic meningiomas were statistically different (p < 0.05) from the other types of meningiomas.
Conclusion:
Perfusion MR imaging can provide useful functional information on meningiomas and help in the preoperative diagnosis of some subtypes of meningiomas.
Insights
Perfusion MRI can help differentiate meningioma subtypes before surgery. Angiomatous meningiomas showed higher tumor blood volume, while anaplastic meningiomas had higher edema blood volume, aiding in preoperative diagnosis.
Area of Science:
- Neurosurgery
- Radiology
- Oncology
Background:
- Meningiomas are the most common primary intracranial tumors.
- Accurate preoperative subtyping of meningiomas is crucial for treatment planning.
- Perfusion magnetic resonance (MR) imaging offers functional insights into tumor characteristics.
Purpose of the Study:
- To evaluate the utility of perfusion MR imaging in the preoperative subtyping of meningiomas.
- To analyze the relative cerebral blood volume (rCBV) in different meningioma subtypes.
Main Methods:
- Thirty-seven meningiomas (15 meningothelial, 10 fibrous, 4 angiomatous, 8 anaplastic) underwent perfusion MR imaging.
- Maximal rCBV was measured in tumoral parenchyma and peritumoral edema.
- Statistical analysis (ANOVA) compared mean rCBVs between histological subtypes.
Main Results:
- Mean tumoral parenchyma rCBV: meningothelial (6.93), fibrous (5.61), angiomatous (11.86), anaplastic (5.89).
- Mean peritumoral edema rCBV: meningothelial (0.87), fibrous (1.38), angiomatous (0.87), anaplastic (3.28).
- Angiomatous meningiomas showed significantly higher tumoral rCBV; anaplastic meningiomas showed significantly higher edema rCBV.
Conclusions:
- Perfusion MR imaging provides valuable functional data for meningioma characterization.
- This technique aids in the preoperative differentiation of specific meningioma subtypes.
- rCBV measurements can potentially distinguish between benign and malignant meningiomas.
