Piroxicam/2-hydroxypropyl-beta-cyclodextrin inclusion complex prepared by a new fluid-bed coating technique

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Drug Delivery Systems

Background:

• Cyclodextrin inclusion complexes enhance drug solubility and bioavailability.
• Traditional methods for preparing inclusion complexes can be complex and time-consuming.

Purpose of the Study:

• To investigate the feasibility of fluid-bed coating for preparing piroxicam-cyclodextrin inclusion complexes.
• To evaluate the physicochemical properties and dissolution enhancement of the prepared complexes.

Main Methods:

• Fluid-bed coating of piroxicam (PIX) and 2-hydroxypropyl-beta-cyclodextrin (HPCD) in an aqueous ethanol solution.
• Characterization using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (PXRD), Fourier Transform-Infrared Spectrometry (FTIR), Raman Spectrometry, and Solid-State (13)C NMR Spectrometry.

Main Results:

• Successful and efficient fluid-bed coating process.
• Significantly enhanced dissolution of PIX (>90% at 5 min) at PIX/HPCD molar ratios of 1/1 and 1/2.
• Confirmation of amorphous PIX and interaction between PIX and HPCD, indicating successful inclusion complex formation.

Conclusions:

• Fluid-bed coating is a promising technique for preparing cyclodextrin inclusion complexes.
• The method offers enhanced drug dissolution and confirmed drug-excipient interactions.
• This technique has potential for industrial application in drug formulation.