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Nephrogenic systemic fibrosis: is gadolinium the missing piece to the puzzle?
Lindsey K Bennett1, Andrea L Garrett
1Department of Dermatology , University of Wisconsin, Madison, 1 South Park St, 7th Floor, Madison, WI 53715 USA. lk.bennett@hosp.wisc.edu
Abstract:
New medical disorders arise infrequently, but nephrogenic systemic fibrosis (NSF) is one such entity. It exclusively affects patients with renal failure, resulting in debilitating progressive fibrosis of the skin and systemic organs. Although much work has been done elucidating the histopathologic changes, a trigger has not been detected. Recently, case reports have implicated gadolinium (Gd) contrast agents as a potential etiology, prompting a health advisory from the US Food and Drug Administration (FDA) in June 2006. We discuss the literature regarding the effects of Gd on tissue and its potential relationship to the known histopathologic characteristics of NSF.
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