Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

VITREOMACULAR TRACTION AFFECTS ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT OUTCOMES FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION.

Retina (Philadelphia, Pa.)·2015

Same author

Deep sclerectomy versus trabeculectomy: a morphological study with anterior segment optical coherence tomography.

The British journal of ophthalmology·2013

Same author

Common spectral domain OCT and electrophysiological findings in different pattern dystrophies.

The British journal of ophthalmology·2013

Same author

[Birdshot chorioretinopathy--case report].

Oftalmologia (Bucharest, Romania : 1990)·2010

Same author

[Familial choroideremia--case report].

Oftalmologia (Bucharest, Romania : 1990)·2010

Same author

[Glomus tumor with diplopia].

Oftalmologia (Bucharest, Romania : 1990)·2009

Same journal

[Macular serpiginous choroiditis complicated by macular hole].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Therapeutic approach in persistent diabetic macular edema].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Preliminary results of treatment with aflibercept].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

MANAGEMENT OF DIABETIC RETINOPATHY, PREVALENCE AND CLINICAL CLASSIFICATION.

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Changes in intraocular pressure depending on posture].

Oftalmologia (Bucharest, Romania : 1990)·2015

Same journal

[Treatment for penetrating wound caused by metallic intraocular foreign body].

Oftalmologia (Bucharest, Romania : 1990)·2015

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 4, 2026

Isolation and Identification of Limbal Niche Cells

Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

[Stem cells in ophthalmology. Pathologic implications].

Alina Stinghe¹

¹Spitalul Clinic de Urgenţă Militar Central Bucureşti, Clinica Oftalmologie.

Oftalmologia (Bucharest, Romania : 1990)

|June 12, 2008

Summary

This summary is machine-generated.

Stem cells are crucial for understanding development and treating diseases. This paper reviews current stem cell knowledge, focusing on ophthalmology and related pathologies.

More Related Videos

Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells

Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells

Published on: October 24, 2018

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

Related Experiment Videos

Last Updated: Jul 4, 2026

Isolation and Identification of Limbal Niche Cells

Isolation and Identification of Limbal Niche Cells

Published on: October 27, 2023

Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells

Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells

Published on: October 24, 2018

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

Area of Science:

Regenerative Medicine
Developmental Biology
Ophthalmology

Context:

Stem cells represent a significant frontier in medical research.
Understanding their role is key to unraveling physiologic development.
Potential therapeutic applications for severe diseases are actively being explored.

Purpose:

To present current knowledge on stem cells.
To specifically detail stem cell applications and implications in ophthalmology.
To discuss associated pathological conditions relevant to ocular stem cell research.

Summary:

This paper provides a comprehensive overview of stem cell biology.
It highlights the specific relevance of stem cells in the field of ophthalmology.
The review connects stem cell functions to ocular diseases and potential treatments.

Impact:

Advances understanding of stem cell potential in medicine.
Offers insights into novel therapeutic strategies for ophthalmic diseases.
Contributes to the growing body of knowledge on stem cell-based regenerative medicine.