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Updated: Jul 4, 2026

Modeling Cataract Surgery in Mice
Published on: December 1, 2023
[Systane and cataract surgery]
C Stefan1, Diana Melinte Dumitrica
1Central Clinical Military Hospital, Bucharest, Romania. cstefan58@yahoo.com
Purpose:
To emphasize and measure the effect of post-cataract surgery Systane treatment.
Setting:
Eye Clinic - Central Clinical Hospital - Bucharest, Romania.
Methods:
Six months clinical, observational, prospective, double-masked study on two groups of patients with cataract surgery (phacoemulsification technique) performed by the same surgeon. Group A (19 patients) received topic treatment with Systane and group B (17 patients) topic treatment with purified water (both with the same presentation form), associated with classical postoperatively treatment. Each patient answered a standardized questionnaire about subjective symptoms of ocular discomfort Several clinical tests were performed for both groups: Schirmer 1 test, tear break-up time (TBUT) and fluorescein staining showing epithelial defects. The groups were homogeneous about the age and sex distribution.
Exclusion Criteria:
any ocular or general associated disease. Statistic analyse: t-student test.
Results:
First examination (after one week treatment) show that 73,68% patients treated with Systane did not have subjective symptoms comparing with 47,05% patients without Systane. Final tests (3 week examination) results for subjective symptoms were improved in both groups: 94,73% group A and 70,58% group B (p<0,001). Abnormal values (under 10 mm) for Schirmer 1 test were found in 17,64% of group B patients comparing with 11,76% patients of group A at the first examination. Final Schirmer 1 test results are statistically better in group A 100%-normal values, comparing with 88,23%-normal values in group B. The stability of tear film (TBUT) is altered in 52,94% of purified water treated patients; only in 21,05% of Systane patients existing this problem at the first examination (p<0,001). After 3 weeks treatment 23,52% group B patients and 5,26% group A patients had TBUT altered. Initially fluorescein staining is present in 4 group B patients and in 1 group A patient, comparing with only 1 group B patient in final tests.
Conclusions:
Cataract surgery can affect ocular tear film production and stability by many factors including postoperatively anti-inflammatory classical treatment. Systane prevents the signs and symptoms of tear film insufficiency, decrease post surgery complications and improve epithelial repair. Systane gives a higher satisfaction to the patient associated with a healthy and stable ocular surface.
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