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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Skin Cancer01:30

Skin Cancer

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Related Experiment Videos

Purple-red papules on foot.

John Patrick Welsh1, Herbert B Allen

  • 1Division of Dermatology, The Western Pennsylvania Hospital, Pittsburgh, PA USA. jp_welsh@hotmail.com

The Journal of Family Practice
|June 12, 2008
PubMed
Summary

An elderly man presented with painful purple-red foot growths. Biopsy revealed a nodular neoplasm, suggesting Kaposi sarcoma, requiring further management.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Presents a case of an 88-year-old male with a history of hypertension and cardiac valve replacement.
  • Patient was on warfarin and nadolol, with no systemic complaints.

Observation:

  • Multiple painful, purple-red papules and nodules on the left foot over several years.
  • Physical examination revealed lower extremity edema and mottled dyspigmentation.

Findings:

  • Punch biopsy demonstrated a nodular neoplasm.
  • Histopathology showed plump spindle-shaped cells in fascicles and extravasated erythrocytes in vascular slits.

Implications:

  • The findings are suggestive of Kaposi sarcoma, a vascular neoplasm.

Related Experiment Videos

  • Diagnosis requires further investigation and appropriate management plan.