Method and device for bio-impedance measurement with hard-tissue applications

Area of Science:

• Biomedical Engineering
• Medical Device Technology

Background:

• Bio-impedance analysis is a valuable non-invasive technique for assessing hard tissue properties.
• Existing methods for hard tissue bio-impedance measurement can be complex or lack portability.

Purpose of the Study:

• To propose a simple method and hardware architecture for hard tissue bio-impedance measurement.
• To present a certified, handheld device for accurate and efficient bio-impedance assessment.

Main Methods:

• Development of a handheld AC impedance device with a 4-channel multiplexer.
• Implementation of a wide impedance measurement range (10 kΩ to 10 MΩ) and frequency range (100 Hz to 100 kHz).
• Integration of user interface features and Bluetooth for wireless data transfer, alongside low-power design for extended use.

Main Results:

• The device is certified to international medical standards.
• Achieved a maximum measurement error of 5% across the specified impedance and frequency ranges.
• Demonstrated over 8 hours of continuous operation through low-power design techniques.
• Bench tests with dummy cells validated performance for resistor-capacitor networks.

Conclusions:

• The proposed method and device offer a simple, portable, and accurate solution for hard tissue bio-impedance measurements.
• The device is suitable for applications in monitoring bone mineral density, fracture healing, and dental caries.
• Wireless data transfer and extended battery life enhance clinical utility and user experience.